What is penicillium allergy

What is penicillium allergy

<p>The <a href=»http://www.geneontology.org/»>Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary divide into 3 categories:<p><a href=’/help/gene_ontology’ target=’_top’>More…</a></p>GO — Molecular functioni

Complete GO annotation on QuickGO …

GO — Biological processi

Complete GO annotation on QuickGO …

Protein family/group databases

Carbohydrate-Active enZymes

More…CAZyi

GH20 Glycoside Hydrolase Family 20


<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href=’/help/family_and_domains_section’ target=’_top’>More…</a></p>Family & Domainsi

Domains and Repeats

Feature key Position(s) DescriptionActions Graphical view Length
<p>This subsection of the <a href=»http://www.uniprot.org/help/family_and_domains_section»>Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href=’/help/domain’ target=’_top’>More…</a></p>Domaini 3 – 61 Glyco_hydro_20

<p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href=»/manual/evidences#ECO:0000259″>More…</a></p> Automatic assertion inferred from signature matchi

AddBLAST

59

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More…eggNOGi

KOG2499 Eukaryota
COG3525 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More…InterProi

View protein in InterPro
IPR025705 Beta_hexosaminidase_sua/sub
IPR015883 Glyco_hydro_20_cat
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More…Pfami

View protein in Pfam
PF00728 Glyco_hydro_20, 1 hit

Protein Motif fingerprint database; a protein domain database

More…PRINTSi

PR00738 GLHYDRLASE20

Superfamily database of structural and functional annotation

More…SUPFAMi

SSF51445 SSF51445, 1 hit


<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href=’/help/names_and_taxonomy_section’ target=’_top’>More…</a></p>Names & Taxonomyi

<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section provides an exhaustive list of every names of the protein, from commonly used to obsolete, to permit unambiguous identification of a protein.<p><a href=’/help/protein_names’ target=’_top’>More…</a></p>Protein namesi

Submitted name:

68 kDa allergen

<p>Information which has been imported from another database using automatic procedures.</p> <p><a href=»/manual/evidences#ECO:0000313″>More…</a></p> Automatic assertion inferred from database entriesi

<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href=’/help/organism-name’ target=’_top’>More…</a></p>Organismi Penicillium chrysogenum (Penicillium notatum)

Automatic assertion inferred from database entriesi

<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein.

This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href=’/help/taxonomic_identifier’ target=’_top’>More…</a></p>Taxonomic identifieri

5076 [NCBI]
<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism.

What is penicillium allergy

It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href=’/help/taxonomic_lineage’ target=’_top’>More…</a></p>Taxonomic lineagei

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Penicillium › Penicillium chrysogenum species complex



Part Description

LP19195-4 Penicillium sp
Test to detect allergy to Penicillium notatum(also known as Penicillium chrysogenum), the allergen code is m1.

Penicillium is the blue-green mold that forms on stale bread, cheese, and other foods and is used in the production of green and blue mold cheese. Penicillium is one of the molds most often producing positive skin test reactions in allergic patients. P notatum is one of the most common species of Penicillium. Penicillium molds prefer damp, dark places, but will also grow elsewhere. Penicillium colonies are rapidly growing, flat, filamentous, and velvety, woolly, or cottony in texture. 11 allergenic components own been identified in P notatum, the major allergen being a 68kDa protein recognized by IgE antibodies in about half the patients. Hypersensitivity to the penicillium mold has no relationship to hypersensitivity to the antibiotic Penicillin.

Copyright Copyright © 2006 Phadia AB.Source: ImmunoCap

Part Descriptions

LP13949-0 Penicillium notatum
Penicillium notatum, also known as Penicillium chrysogenum, is a mold commonly found in most homes from which Beta-lactam antibiotics are extracted. Penicillium is known as the blue-green mold on bread, fruits, and nuts. It is also used for the production of green and blue mold cheese.

Penicillium grows best in spring and winter, but the mold has no seasonal variation.

What is penicillium allergy

It is a well-known group of brushed-shaped microorganisms belonging to the fungimycin family, and has no known sexual state. Penicillium is heterotrophic. Copyright Text is available under the Creative Commons Attribution/Share-Alike License.

What is penicillium allergy

See http://creativecommons.org/licenses/by-sa/3.0/ for details.Source: Wikipedia, Penicillium notatum (Wikipedia)

LP13949-0 Penicillium notatum
A mold that may result in allergy symptoms in sensitized individuals. Penicillium is the blue-green mold found on stale bread, fruits and nuts, and used for production of green and blue mold cheese.

Penicillium has endless been recognised as one of the molds most often producing positive skin test reactions in allergic individuals.

Inhalation of Penicillium spores in quantities comparable with those encountered by natural exposure can induce both immediate and tardy asthma in sensitive persons. Sensitivity to Penicillium bears no relationship to sensitivity to the antibiotic Penicillin. Copyright Copyright © 2006 Phadia AB.Source: ImmunoCap, ImmunoCap

Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease and to define the allergens responsible for eliciting signs and symptoms.

Testing also may be useful to identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm sensitization to specific allergens prior to beginning immunotherapy, and to investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens.

Clinical manifestations of immediate hypersensitivity (allergic) diseases are caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE antibodies interact with allergen.

In vitro serum testing for IgE antibodies provides an indication of the immune response to allergen(s) that may be associated with allergic disease.

The allergens chosen for testing often depend upon the age of the patient, history of allergen exposure, season of the year, and clinical manifestations.

In individuals predisposed to develop allergic disease(s), the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).

Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.

The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.

Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.

Some individuals with clinically insignificant sensitivity to allergens may own measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

False-positive results for IgE antibodies may happen in patients with markedly elevated serum IgE (>2,500 kU/L) due to nonspecific binding to allergen solid phases.

Homburger HA: Chapter 53: Allergic diseases.

What is penicillium allergy

In Clinical Diagnosis and Management by Laboratory Methods. 21st edition. Edited by RA McPherson, MR Pincus. WB Saunders Company, New York, 2007, Part VI, pp 961-971


Special InstructionsLibrary of PDFs including pertinent information and forms related to the test

AF011: Eukaryotic elongation factor 1

Biochemical properties

Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to the ribosomes.

What is penicillium allergy

It is composed of four subunits. The β and δ chains are highly similar proteins that both stimulate the exchange of GDP bound to the α chain for GTP [1]. On their N-termini, they contain a domain similar to the C-terminal domain of glutathione S-transferase (AllFam:AF010).

What is penicillium allergy

Allergens from this family

Pen c 24, a minor allergen from Penicillium citrinum was identified as EF-1β [2].

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References

  • Le Sourd F, Boulben S, Le Bouffant R, Cormier P, Morales J, Belle R, Mulner-Lorillon O:
    eEF1B: At the dawn of the 21st century.
    Biochim Biophys Acta 2006, 1759, 13-31. [PubMed][Full Text]
  • Tang RB, Chen YS, Chou H, Lee SS, Tai HY, Shen HD:
    cDNA cloning and immunologic characterization of a novel EF-1beta allergen from Penicillium citrinum.
    Allergy 2005, 60, 366-71. [PubMed][Full Text]

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Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00736 EF-1 guanine nucleotide exchange domain
PF10587 Eukaryotic elongation factor 1 beta central acidic region

Links to Wikipedia

[top]

If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

Submitted name:

68 kDa allergen

N/A

Penicillium chrysogenum (Penicillium notatum)

Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href=’/help/annotation_score’ target=’_top’>More…</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein.

Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href=’/help/protein_existence’ target=’_top’>More…</a></p>

Select a section on the left to see content.

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Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00736 EF-1 guanine nucleotide exchange domain
PF10587 Eukaryotic elongation factor 1 beta central acidic region

Links to Wikipedia

[top]

If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

Submitted name:

68 kDa allergen

N/A

Penicillium chrysogenum (Penicillium notatum)

Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.

What is penicillium allergy

This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href=’/help/annotation_score’ target=’_top’>More…</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href=’/help/protein_existence’ target=’_top’>More…</a></p>

Select a section on the left to see content.


<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href=’/help/pathology_and_biotech_section’ target=’_top’>More…</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More…Allergomei

3408 Pen ch 20.0101
526 Pen ch 20


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