What is meant by atopic allergy

Kouadio Celestin Ahogo1, Yao Isidore Kouassi1, Ildevert Patrice Gbery1, Kouadio Richard Azagoh2, Kouame Issouf Yeboua1, Kouame Alexandre Kouassi1, Ange Sylvain Allou1

1Dermatology Service, Félix Houphouët Boigny University, CHU Treichville, Abidjan, Côte d’Ivoire, 2Pediatric service, Félix Houphouët Boigny University, CHU Treichville, Abidjan, Côte d’Ivoire

Corresponding author: Dr. Kouadio Celestin Ahogo, E-mail: [email protected]

Submission: 04.08.2017; Acceptance: 27.10.2017

DOI: 10.7241/ourd.2017s.6


ABSTRACT

Few studies own been devoted to atopic dermatitis in children in sub-Saharan Africa.

We therefore make this study in Côte d’Ivoire in order to contribute to a better knowledge of atopic dermatitis in children on black skin. In our study the prevalence was 9.2%. The duration of the disease before the consultation ranged from 3-45 days. Atopic dermatitis occurs more frequently in children from2 to 5 years ancient. More than half of the patients had a history of atopy and the lesions generally were localized in the folds.

60% of the lesions were dry and were trigged by dust. The pruritus was often insomnia and the scratching leads to hyperpigmentation of the lower eyelid; a characteristic sign on black skin not often reported in the literature.

Key words: Atopic dermatitis, Children, Black skin, Cote d’Ivoire


RESULTS

On epidemiologic stage, 70 cases of atopic dermatitis own been recorded out of a entire of 765 children seen in consultation. The prevalence of atopic dermatitis in children was 9.2%. 52.9% of the patients were male with a sex ratio (M/F)at 1.1.

The age of the children’s ranged from 6 months to 13 years. Children from 2 to 5 years represented 42.9% of the patients, followed by the age group from 6 to 13 years (30%). The duration of the disease before the consultation ranged from 3-45 days. Outbreaks of the disease were more than 15 days in 72.4% of cases.

A triggering factor was found in 15.7% of our patients, it was mainly dust (17.1%)and perfumes (5.7%). The personal and family histories of atopy are represented in Table I.

Table 1: Personal and family histories of atopy

The types of eczema observed were: dry (60%), oozing (32.9%), and lichenification (07.1%). These lesions were found in the folds (54.3%), the trunk (51.4%), the legs (31.4%), and the face (30%)with pigmentation of the lower eyelid (7.1%).

The scalp (22.9%)and generalized (02.9%).

What is meant by atopic allergy

Atopic dermatitis was minor in 57.1% of cases, moderate (40%), and severe (2.9%); the other signs of atopic dermatitis observed in children are represented in Table II. Complications were observed in 58.57% of children. These included insomnia pruritus (44.3%), bacterial (12.9%)and viral (1.4%)secondary infection.

Table 2: Other signs of atopic dermatitis

Ethics Statement

This article has been written by these authors, it has not been send or published by another journal.

DISCUSSION

70 cases of atopic dermatitis was observed among 765 pediatric dermatoses, the prevalence was therefore 9.2%.

In Western Europe, the prevalence of atopic dermatitis in children is between 10-20% [3,4]. The most affected age group in the study was 2 to 6 years. In fact, atopic dermatitis often begins duringthe first year of life (the new born)and decreases around the age of 5 years. 54.2% of the children had a history of atopic disease. These included allergic rhinitis (37.1%), asthma (25.7%)and allergic conjunctivitis (17.1%). Six (06)of our patients regularly developed a food allergy. The association of several atopic clinical signs in the same patient is classic but inconstant [5,6].

What is meant by atopic allergy

The duration of relapses was in 72.4% of cases longer than 15 days. This could be explained in our context by self-medication. In one-quarter of the patients dust (17.1%)was the triggerfactor. Atopic dermatitis is a multifactorial disease modulated by genetic and environmental influences [7,8]. Concerning the clinical aspects, atopic dermatitis in our study was predominantly in folds (54.3%). This predominance in folds was mostly observed in children over 2 years of age. As for the nursling, they had mainly facial lesions. Dry lesions (60%)were the most frequent, followed by oozing lesions (32.9%).

Seepage often represents an entry point for bacterial and viral complications of atopic dermatitis [9,10]. In fact, bacterial secondary infection occurred in 12.9% of cases. Lichenification was present in 7.1% of our patients.

What is meant by atopic allergy

Chronic scratching is the main factor of thisLichenification. Insomnia pruritus was found in 44.3% of our patients. Pruritus leads to sleep disturbances, sometimes with children’s growth retardation [11].

What is meant by atopic allergy

Instead, hyperpigmentation was observed on thelower eyelid (7.1%). This characteristic sign most visible on dark skin is due to chronic friction.

MATERIALS AND METHODS

This was a prospective study, with descriptive and analytical sight over 12 months. The target population waspatients seen in consultation over the period of our study. Boys and girls from 0 to 15 years with atopic dermatitis were included in the study.

Data from the study were collected on an inquiry sheet that included socio-demographic and clinical data.

CONCLUSION

Atopic dermatitis in Côte d’Ivoire occurs more frequently in children from 2 to 5 years ancient. More than half of the patients had a history of atopy and the lesions generally localized in the folds.

What is meant by atopic allergy

These were mainly dry lesions most often triggered by dust. The pruritus was often insomnia and the scratching lead to hyperpigmentation of the lower eyelid; a characteristic sign on black skin not often reported in the literature.

INTRODUCTION

Atopic dermatitis or constitutional eczema generally occurs in children in a specific condition called atopy. Its pathophysiological, epidemiological, clinical and therapeutic aspects own been the subject of several studies in Europe and in America [1,2].

However, few studies own beendevoted to atopic dermatitis in sub-Saharan Africa. Therefore, we proposed to make this study in order to contribute to a better knowledge of atopic dermatitis in children, on black skin in Africa.

RÉFÉRENCES

1.Catteau B. Atopic dermatitis:current epidemiology and clinical data. French J Allergol Clin Immunol. 2002;42:373-7.

2.Schmitt J, Langan S, Deckert S, Svensson A, von Kobyletzki L, Thomas K, et al. Assessment of clinical Signs of atopic dermatitis:A systematic review and recommendation.

J Allergy Clin Immunol. 2013;132:1337-47.

3.Taïeb A. Atopic dermatitis:definition, epidemiology, natural history, gravity and scores. Ann Dermatol Venereol. 2005132:35-43.

4.Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, et al. Diagnosis and treatment of atopic dermatitis in children and adults:European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report.

J Allergy Clin Immunol. 2006;118:152-69.

5.Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends In the prevalence of symptoms of asthma, allergic rhinitis conjunctivitis, and eczema in childhood:ISAAC Phases One and Three repeat multi-cross-sectional surveys. Lancet. 2006;368:733-43.

6.The prevalence of asthma, rhinitis and eczema in 13 to 14 years ancient children in Africa:The ISAAC Phase III. Allergy. 2007;3:247-58.

7.Borralevi T, Hubiche T, Léauté-Labrèze C, Saubusse E, Fayon M, Roul S, et al.

Epicutaneous aeroallergen sensitization in atopic dermatitis infants determine the role of epidermal barrier impairment. Allergy. 2008;63:205-10.

8.Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010;107:11971-5.

9.Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, et al.

What is meant by atopic allergy

Guidelines for the management of atopic dermatitis:section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71:116-32.

10.Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, et al. Temporal shifts in the skin Atopic dermatitis. Genome Res.

What is meant by atopic allergy

2012;22:850-9.

11.Silverberg JI, Simpson EL. Association between severe eczema in children and multiple comorbid conditions and increased health care utilization. Pediatr Allergy Immunol. 2013;24:476-86.

Notes

Source of Support: Nil

Conflict of Interest: None declared.

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Sequence databases

O93972-1 [UniParc]FASTAAdd to basketAdded to basket« Hide 10 20 30 40 50
MVALKFAAVL SVVAAAVMAA PSSMDRRASP DNQVWVTSAS DYCLILPRHR
60 70 80 90 100
ESIGDSESPG RMRSFCSKPY DSSQGQINPG FWKEVHFKKT KNYVQLTGCI
110 120 130 140 150
NPRVQSTLLS HDDGGQYDSN GNGGVGNPEG SVCLGYSSYV ELVEPSDGKA
160 170
CIRCCVNDKY CDVGHDEDGC EAVIPGQYC
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May 1, 2000 — v2

20205B134D662C4E

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Allergomei 3372 Mala s 8.0101
474 Mala s 8

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O93972_MALSM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href=’/help/accession_numbers’ target=’_top’>More…</a></p>Accessioni O93972Primary (citable) accession number: O93972
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the final sequence update and the date of the final annotation modification (‘Last modified’).

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Integrated into UniProtKB/TrEMBL: May 1, 1999
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