What is in latex that causes allergy

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href=’/help/sequence_similarities’ target=’_top’>More…</a></p>Sequence similaritiesi

To kiwi fruit protein PKIWI501.


<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href=’/help/names_and_taxonomy_section’ target=’_top’>More…</a></p>Names & Taxonomyi

<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section provides an exhaustive list of every names of the protein, from commonly used to obsolete, to permit unambiguous identification of a protein.<p><a href=’/help/protein_names’ target=’_top’>More…</a></p>Protein namesi

Recommended name:

Major latex allergen Hev b 5

Alternative name(s):

Allergen: Hev b 5

<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href=’/help/organism-name’ target=’_top’>More…</a></p>Organismi Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein.

This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href=’/help/taxonomic_identifier’ target=’_top’>More…</a></p>Taxonomic identifieri

3981 [NCBI]
<p>This subsection of the <a href=»http://www.uniprot.org/help/names_and_taxonomy_section»>Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href=’/help/taxonomic_lineage’ target=’_top’>More…</a></p>Taxonomic lineagei cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliopsida › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Malpighiales › Euphorbiaceae › Crotonoideae › Micrandreae › Hevea


<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href=’/help/pathology_and_biotech_section’ target=’_top’>More…</a></p>Pathology & Biotechi

<p>This subsection of the <a href=»http://www.uniprot.org/manual/pathology_and_biotech_section»>’Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals.

We generally specify in which species the protein is allergenic.<p><a href=’/help/allergenic_properties’ target=’_top’>More…</a></p>Allergenic propertiesi

Causes an allergic reaction in human. Major latex allergen, a major cause of anaphylaxis in susceptible individuals, especially health care workers. 92% of health care workers with latex allergy own IgE specific to the Hev b 5 protein.

<p>UniProtKB Keywords constitute a <a href=»http://www.uniprot.org/keywords»>controlled vocabulary</a> with a hierarchical structure.

Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href=’/help/keywords’ target=’_top’>More…</a></p>Keywords — Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More…Allergomei

3316 Hev b 5.0101
389 Hev b 5


Major latex allergen Hev b 5

N/A

Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)

Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.

This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href=’/help/annotation_score’ target=’_top’>More…</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href=’/help/protein_existence’ target=’_top’>More…</a></p>

Select a section on the left to see content.


<p>This section displays by default the canonical protein sequence and upon request every isoforms described in the entry.

It also includes information pertinent to the sequence(s), including <a href=»http://www.uniprot.org/help/sequence_length»>length</a> and <a href=»http://www.uniprot.org/help/sequences»>molecular weight</a>. The information is filed in diverse subsections. The current subsections and their content are listed below:<p><a href=’/help/sequences_section’ target=’_top’>More…</a></p>Sequencei

<p>This subsection of the <a href=»http://www.uniprot.org/help/sequences_section»>Sequence</a> section indicates if the <a href=»http://www.uniprot.org/help/canonical_and_isoforms»>canonical sequence</a> displayed by default in the entry is finish or not.<p><a href=’/help/sequence_status’ target=’_top’>More…</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href=»http://www.uniprot.org/help/sequences_section»>Sequence</a> section indicates if the <a href=»http://www.uniprot.org/help/canonical_and_isoforms»>canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href=’/help/sequence_processing’ target=’_top’>More…</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically athletic derived peptide(s).<p><a href=’/help/mass_spectrometry’ target=’_top’>More…</a></p>Mass spectrometryi

Molecular mass is 16001.2 Da.

Sure by MALDI.

<p>Manually curated information for which there is published experimental evidence.</p> <p><a href=»/manual/evidences#ECO:0000269″>More…</a></p> Manual assertion based on experiment ini

  1. «A novel acidic allergen, Hev b 5, in latex. Purification, cloning and characterization.»
    Akasawa A., Hsieh L.-S., Martin B.M., Liu T., Lin Y.
    J. Biol. Chem. 271:25389-25393(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY.

Sequence databases

Q39967-1 [UniParc]FASTAAdd to basketAdded to basket« Hide 10 20 30 40 50
MASVEVESAA TALPKNETPE VTKAEETKTE EPAAPPASEQ ETADATPEKE
60 70 80 90 100
EPTAAPAEPE APAPETEKAE EVEKIEKTEE PAPEADQTTP EEKPAEPEPV
110 120 130 140 150
AEEEPKHETK ETETEAPAAP AEGEKPAEEE KPITEAAETA TTEVPVEKTE

E
Show »

151

16,090

January 23, 2007 — v3

1E5E1B73E9715CD5

GO


So, You’ve Been Diagnosed with Hives!

by Richard S.

Roberts, M.D.

Chronic Hives

So, if acute hives don’t seem to own an allergic cause what else could be going on? One of the more common presumed causes, especially in children is post-infectious hives. During or within a week of viral, strep or other infections hives may happen through poorly understood mechanisms. This often leads to confusion when antibiotics own been given for the infection. Were the hives from the antibiotic or from the underlying illness? Post-infectious hives can recur for up to 6 weeks. At times, even without infection or any obvious trigger a few hours to a few days of hives happen. These are called acute idiopathic hives.

We assume that the immune system is inappropriately activating the skin mast cells but we don’t know why. We don’t ponder that stress is a common cause.

So, your hives own gone on for more than 6 weeks, so they drop into the chronic urticaria category. Now what? Once again you’re not alone. Approximately 3 million Americans of every ages own the same problem.

What is in latex that causes allergy

There are some significant things that you should know. The first is that, unlike acute urticaria, less than 5% of the cases are due to some external cause. Also, unlike acute urticaria, the hives and /or swelling are rarely dangerous. In this form of hive problem various quirks and idiosyncrasies of the immune system, as they relate to mast cells, are the primary cause.

Our understanding of the problem is improving but there are numerous unanswered questions.

What is in latex that causes allergy

The best understood of these idiosyncrasies is called chronic autoimmune urticaria. Approximately 45% of every chronic hives are of this type.

What is in latex that causes allergy

In this condition the immune system makes a detectable antibody (for which we own a test) that mistakenly thinks that parts of the mast cell surface are the enemy. This antibody attacks the skin mast cells which leads to the release of histamine, etc. It’s been known for a endless time that if our body makes one autoantibody type of error it’s easier for it to make other autoantibody mistakes. Therefore, it’s not terribly surprising that in chronic autoimmune urticaria approximately 20% of patients, especially women, will also own autoantibodies that target the thyroid gland.

This may lead to Hashimoto’s thyroiditis and periodically blood tests for thyroid function should be checked. Unfortunately, treating this thyroid condition probably does not benefit the hives.

The next most common type of chronic urticaria is chronic idiopathic urticaria. This condition is almost certainly due to the immune system’s interaction with mast cells but the details are unknown. Both chronic autoimmune and chronic idiopathic urticaria may worsen during febrile illnesses, with the use of aspirin family medicines, prior to the monthly menstrual period or with sustained pressure to or rubbing of the skin.

Individual hives that sting more than itch, leave bruises and final 3 or more days may indicate hives due to vasculitis (inflammation of the blood vessels).

Other forms of chronic hives own to do with the immune system’s reaction to physical triggers. Hives produced by stroking of the skin is called dermographism. Some people’s hives are triggered just by freezing, heat, skin pressure, vibration, exercise, sun or even water. These conditions are fairly rare. Some exercise induced patients can either react just to exercise while others react only if their exercise follows the consumption of a food to which they are mildly allergic, most commonly wheat, celery and shellfish.

These exercise reactions can produce anaphylaxis and may be dangerous. Another dangerous condition, this one involving angioedema and never hives, is called hereditary angioedema. In these patients swelling of the upper airway can be fatal. Such patients also generally own pronounced abdominal pain from swelling of their intestines. Treatment is available.

So, now that you’ve put your hives into a category how are they treated? For acute hives and rare cases of chronic hives avoidance of triggers is the key. If the acute hives are already present antihistamines and if severe, a short course of oral steroid is used.

What is in latex that causes allergy

For chronic hives daily preventative antihistamines are essential. Doses higher than those used for nasal allergy treatment are often needed. If maximum antihistamine dosing has been reached without control, addition of an H2 blocker (e.g. Tagamet) and/or a leukotriene blocker (e.g. Singulair) may be tried.

What is in latex that causes allergy

Maximizing the above therapy should minimize the need for oral steroid. Relying on recurrent courses of oral steroids (prednisone) especially without full antihistamine, H2 blocker and anti-leukotriene support is to be discouraged.

What is in latex that causes allergy

In rare cases cyclosporin or other immunomodulatory medicines may be added. Once control has been achieved medicines should be continued for several weeks or longer past the final symptoms. Slow tapering can then be attempted.

Allergy Hives

So, why are my mast cells releasing histamine and other things when they shouldn’t? The first question that needs to be asked is for how endless own you had hives? Hives that own been present intermittently or daily for less than 6 weeks are called acute hives, and if longer, chronic hives. Amongst the numerous possible causes of acute hives those due to allergic reactions get the most attention.

In allergic patients the mast cells are coated with an allergy antibody, called IgE, that recognizes a extremely specific target (peanut, penicillin, yellow jacket, etc.). When that substance, such as peanut, becomes attached to that allergy antibody a chain reaction occurs that activates the mast cell which results in the release of histamine and other inflammatory substances. A hive is born! For food allergy reactions, there are 3 useful rules to consider:

  1. Second, it goes away within a few hours or at the most within a day or two. Therefore, you never get hives for a week from one serving of peanut butter.
  2. First, the reaction begins quickly, within 5-30 minutes of eating the food; on rare occasions up to an hour but almost never longer.
  3. Third, the reaction is reproducible, meaning that if hives were caused by eating 4 peanuts on a Monday, eating 4 peanuts the following week will almost always cause the same problem.

    Despite favorite belief, artificial food colorings and food additives almost NEVER cause hives.

Hives from antibiotics is a diverse situation. The hive reaction can start anywhere from a few minutes after the first dose to 10 days after finishing the course. Antibiotic related hives can persist for up to approximately 2 weeks.

Allergic hives from stinging insects are generally obvious but occasionally they can be sneaky by occurring while you’re asleep or distracted. They start quickly after the sting and resolve in a few hours to a few days.

In the U.S. spiders, flies and mosquitoes almost never cause hives although rare cases own been reported.

Almost any medicine or herbal product can potentially cause hives but one of the most common medicines implicated is the aspirin family (aspirin, ibuprofen, naproxen, etc.). Isolated swelling without hives is a unique side effect of the ACE inhibitor blood pressure medicines. Soaps, detergents, fabric softeners almost never cause hives but if they do, the hives happen only where the skin is touched. Airborne allergy to pollen, dust, etc. almost never causes hives unless the person is in the midst of a massive hay fever attack.

In an allergic person, direct skin contact with a potent allergic substance love animal saliva or latex can cause hives at the site. Every categories of allergic hives are potentially dangerous while chronic hives are generally not.

Do you really own the Hives?

Don’t despair. You’re not alone. Approximately 20% of the population will own hives (urticaria) at one time or another during their lifetime. First off, are you certain that they’re really hives? True hives are red, itchy, generally raised lesions that look very much love mosquito bites. They are often circular or oval but can be  irregularly shaped.

Their size may vary from ¼ inch to several inches in diameter. They may blend together. Each spot lasts anywhere from 4-36 hours and is surrounded by normal looking skin. As they resolve the skin looks normal, not flaky or rough. While the hives are present one spot will be resolving while another nearby is developing. In about 40% of cases localized swelling (angioedema) of the lips, eyelids, hands, feet or tongue also occurs.
So, if these are really hives they must be from an allergy, right? Well, unfortunately it’s not that simple and modern science doesn’t own every of the answers.

The history of how they first appeared and what’s happened to them since can provide significant clues as to what category of hives you own. But first, what actually is a hive? Everyone’s skin is made up of numerous types of cells. One of these cells is called a mast cell. Everyone’s mast cells make and store histamine. They also routinely make leukotrienes and other substances that can cause localized inflammation. Mast cells don’t generally release much of these substances into the surrounding skin but if they do, these substances, especially histamine produce localized redness, itch and swelling we recognize as a hive or if it’s slightly deeper, angioedema.

Conclusion

So, what’s my prognosis Doc?

As noted above:

  1. Less than 30% of idiopathic acute hives will go on to be chronic.
  2. Acute hives resolve spontaneously.
  3. If you own chronic hives that aren’t of the “physical” type at least 50% will resolve in less than a year and another 20% will resolve over the next several years.

    The “physical” hives tend to be more endless lasting.

Research is ongoing in every of these areas. So hold your chin up, take your antihistamine, and get the necessary attention to the type of hives that you have.


<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href=’/help/ptm_processing_section’ target=’_top’>More…</a></p>PTM / Processingi

<p>This subsection of the <a href=»http://www.uniprot.org/help/ptm_processing_section»>PTM/processing</a> section describes post-translational modifications (PTMs).

This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href=’/help/post-translational_modification’ target=’_top’>More…</a></p>Post-translational modificationi

The N-terminus is blocked.

Amino acid modifications

Feature key Position(s) DescriptionActions Graphical view Length
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href=»http://www.uniprot.org/manual/lipid»>lipids</a>, <a href=»http://www.uniprot.org/manual/carbohyd»>glycans</a> and <a href=»http://www.uniprot.org/manual/crosslnk»>protein cross-links</a>.<p><a href=’/help/mod_res’ target=’_top’>More…</a></p>Modified residuei 2 N-acetylalanine 1

Molecule processing

Feature key Position(s) DescriptionActions Graphical view Length
<p>This subsection of the <a href=»http://www.uniprot.org/help/ptm_processing_section»>PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href=’/help/init_met’ target=’_top’>More…</a></p>Initiator methioninei Removed
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href=’/help/chain’ target=’_top’>More…</a></p>ChainiPRO_0000064561 2 – 151 Major latex allergen Hev b 5AddBLAST 150

Keywords — PTMi

Acetylation

Proteomic databases


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