What is a sulfonamide allergy

What is a sulfonamide allergy

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Symptoms

The symptoms and severity of a sulfa allergy can vary but generally involve the appearance of a widespread rash. Occasionally a photosensitive rash may develop, meaning that a rash will happen in areas exposed to sunlight or other UV light while on the medication.

Other serious manifestations of a sulfa allergy include:


Sulfonamide Allergy

Aka: Sulfonamide Allergy, Sulfa Allergy

  • See Also
    • Sulfonamide
  • Pharmacology
  • Pharmacology
    • Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
    • Sulfonamide Allergy does not cross react with sulfur, sulfate, Sulfites
  • Preparations: Sulfonylarylamines (Sulfa agents)
  • Preparations: Sulfonylarylamines (Sulfa agents)
  • General
    • Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
  • Sulfa Antibiotics
  • Sulfa Antibiotics
    • Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
    • Sulfadiazine
    • Sulfacetamide
  • Sulfa Antiinflammatories
  • Sulfa Antiinflammatories
    • Sulfasalazine
  • Protease Inhibitors (HIV Infection)
  • Protease Inhibitors (HIV Infection)
    • Darunavir (Prezista)
    • Fosamprenavir (Lexiva)
  • Preparations: Non-Sulfonylarylamines
  • Preparations: Non-Sulfonylarylamines
  • General
    • Similar structure to Sulfonylarylamines , but hypersensitivity cross-reactivity is uncommon
    • However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
  • Diuretics
  • Diuretics
    • All Thiazide Diuretics
    • Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
  • Anti-hyperglycemics (Diabetes Mellitus)
  • Anti-hyperglycemics (Diabetes Mellitus)
    • Sulfonylureas (e.g.

      Glipizide)

  • Analgesics
  • Analgesics
    • Celecoxib (Celebrex)
  • Preparations: Sulfonamide Moieties
  • Preparations: Sulfonamide Moieties
  • General
    • Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
    • However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
  • Neurologic agents
  • Neurologic agents
    • Sumatriptan (Imitrex)
    • Topiramate (Topamax)
    • Zonisamide (Zonagran)
  • Protease Inhibitor (Hepatitis C Infection)
  • Protease Inhibitor (Hepatitis C Infection)
    • Simeprevir (Olysio)
  • References
  • References
    • (2014) Presc Lett 21(2): 10-11
    • Ghimire (2013) J Clin Pharm Ther 38: 196–202 [PubMed]
    • Wulf (2013) Am J Health Syst Pharm 70:1483-94 [PubMed]

    Images: Related links to external sites (from Bing)

    Related Studies

    Ontology: Allergy to sulfonamides (C0038757)

    Concepts Disease or Syndrome (T047)
    SnomedCT 91939003
    English SULFA ALLERGY, allergy sulfas, allergy to sulfa drugs, allergies drugs sulpha, allergies drug sulfa, allergy sulfa, sulfa drugs allergy, allergies sulfonamide, sulfa allergy, allergies sulfa, sulfonamide allergy, allergy drug sulfa, allergy drug sulpha, Sulfonamide allergy, Sulphonamide allergy, Allergy to sulfa drugs, Allergy to sulfonamides, Allergy to sulfonamides (disorder), Allergy to sulpha drugs, Allergy to sulphonamides
    Dutch allergie voor sulfonamide
    French Allergie aux sulfonamides
    German Sulfonamidallergie
    Italian Allergia alla sulfonamide
    Portuguese Alergia a sulfonamida
    Spanish Alergia a sulfonamidas, alergia a las sulfamidas, alergia a las sulfonamidas (trastorno), alergia a las sulfonamidas
    Japanese スルホンアミドアレルギー, スルホンアミドアレルギー
    Czech Alergie na sulfonamidy
    Hungarian Szulfonamid allergia

    Sulfa allergy is a term used to describe an adverse drug reaction to sulfonamides, a class of drugs that includes both antibiotics and non-antibiotics.

    Ideally, a physician will document what specific sulfa drug was associated with what specific reaction as the term "sulfa allergy" alone may unnecessarily lead to avoidance of drugs that may be tolerated.

    There's a common misconception that every sulfonamide drugs are equally likely to cause an allergic or adverse reaction, but this isn't true.

    (All drugs own the potential to cause allergy.) Antibiotic sulfonamides (used to treat bacterial infections) are more likely to trigger an allergic reaction than nonantibiotic ones.

    While every drugs own the potential to cause an allergy, non-antibiotic sulfonamides are less likely sources.

    Images: Related links to external sites (from Bing)

    Related Studies

    Ontology: Allergy to sulfonamides (C0038757)

    Concepts Disease or Syndrome (T047)
    SnomedCT 91939003
    English SULFA ALLERGY, allergy sulfas, allergy to sulfa drugs, allergies drugs sulpha, allergies drug sulfa, allergy sulfa, sulfa drugs allergy, allergies sulfonamide, sulfa allergy, allergies sulfa, sulfonamide allergy, allergy drug sulfa, allergy drug sulpha, Sulfonamide allergy, Sulphonamide allergy, Allergy to sulfa drugs, Allergy to sulfonamides, Allergy to sulfonamides (disorder), Allergy to sulpha drugs, Allergy to sulphonamides
    Dutch allergie voor sulfonamide
    French Allergie aux sulfonamides
    German Sulfonamidallergie
    Italian Allergia alla sulfonamide
    Portuguese Alergia a sulfonamida
    Spanish Alergia a sulfonamidas, alergia a las sulfamidas, alergia a las sulfonamidas (trastorno), alergia a las sulfonamidas
    Japanese スルホンアミドアレルギー, スルホンアミドアレルギー
    Czech Alergie na sulfonamidy
    Hungarian Szulfonamid allergia

    Sulfa allergy is a term used to describe an adverse drug reaction to sulfonamides, a class of drugs that includes both antibiotics and non-antibiotics.

    Ideally, a physician will document what specific sulfa drug was associated with what specific reaction as the term "sulfa allergy" alone may unnecessarily lead to avoidance of drugs that may be tolerated.

    There's a common misconception that every sulfonamide drugs are equally likely to cause an allergic or adverse reaction, but this isn't true.

    What is a sulfonamide allergy

    (All drugs own the potential to cause allergy.) Antibiotic sulfonamides (used to treat bacterial infections) are more likely to trigger an allergic reaction than nonantibiotic ones.

    While every drugs own the potential to cause an allergy, non-antibiotic sulfonamides are less likely sources.


    Diagnosis

    There's no validated skin or blood test available to diagnose a sulfa allergy. The diagnosis is generally made on careful review of the suspected reaction and history of current and previous medication use.


    Overview

    In the majority of cases, a person with a sulfa allergy will own experienced an allergic reaction to one or more of the following antibiotic drugs:

    1. Septra (sulfamethoxazole and trimethoprim)
    2. Bactrim (sulfamethoxazole and trimethoprim)
    3. Pediazole (erythromycin and sulfafurazole)

    These reactions are not every that unusual and affect around 3 percent of every people. This is a rate similar to what is seen with other types of antibiotics, including penicillin.

    Certain people appear to be at higher risk of sulfa allergy than others.

    These include those who, for various reasons, own a suppressed immune system (such as organ transplant recipients and people with HIV/AIDS).


    Treatment

    The first-line of treatment of a sulfa allergy is typically the termination of the suspected drug.

    Anaphylaxis requires immediate epinephrine use and medical care.

    Stevens-Johnson syndrome or toxic epidermal necrolysis are also potentially life-threatening conditions that require immediate medical evaluation; in severe cases, management in a burn unit may be required.

    In milder cases where a sulfa drug is considered essential to the treatment of an infection, an allergist or other qualified physician may supervise the istration of smaller doses and gradually increase them as the drug is better tolerated.


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    What is a sulfonamide allergy