What is a good vitamin for allergies
The researchers analysed 433 studies with a entire of 1,506,815 participants – 260 of these studies covered milk feeding and 173 covered other maternal or baby diets.
Children who had been exposed to probiotic supplements, either directly through supplemented formula or via their mother`s diet when pregnant or breastfeeding, were 22% less likely to get eczema, based on 19 trials (relative risk [RR] 0.78, 95% confidence interval [CI] 0.68 to 0.9). The researchers were moderately certain about these results, which equate to about 44 fewer cases per 1,000 children. It`s unclear whether the trials mostly looked at supplementation during pregnancy and breastfeeding, or supplementation of the infant`s diet.
Children born to women who took fish oil supplements during pregnancy and breastfeeding were 31% less likely to show a sensitivity to egg at age 1, based on 6 trials (RR 0.69, 95% CI 0.53 to 0.9).
The researchers were moderately certain about these results, which equate to about 31 fewer cases per 1,000 children. These children were also 38% less likely to show a sensitivity to peanuts, but this was based on only 2 trials (RR 0.62, 95% CI 0.4 to 0.96).
Breastfeeding for longer was associated with a lower risk of the kid getting recurrent wheeze (a sign of asthma), but the researchers said they had low certainty about these results, partly because these were observational studies that didn`t completely take account of potential confounders.
Avoiding certain foods while pregnant or breastfeeding did not seem to reduce the risk of allergy.
The researchers also found no convincing results for other types of supplements or for any specific type of diet, such as eating more vegetables.
They said tests of their results showed more certainty for the probiotic supplements than the fish oil supplements.
What helpful of research was this?
This study was a systematic review and meta-analysis. It included randomised controlled trials of interventions such as supplements, and observational studies of behaviour such as breastfeeding and general diet to see whether there were any links with children`s allergies.
These types of study are the best way to get a excellent overview of the state of research on a topic, and a meta-analysis can be a useful way of pooling results from numerous diverse studies. However, the overall findings are only as dependable as the underlying studies.
Because allergies are so common among children and can own a major effect on their lives, anything that helps us understand how to reduce the risk is extremely welcome.
This study suggests certain aspects of women`s diets during pregnancy and while breastfeeding, as well as infant-feeding practices, may own an effect on the development of allergies in children.
However, plenty of questions remain.
The study doesn`t clearly tell us which probiotic supplements were taken in studies, at what dose or by whom. There isn`t enough clear evidence for us to know whether pregnant women, infants or both may benefit from taking supplements. That means recommendations can`t be made from this study.
Also, while lots of people eat probiotic yoghurts, we don`t know if these contain sufficient probiotic bacteria to be helpful or whether they are the correct strains of probiotics.
Moreover, while fish oil supplements during pregnancy or breastfeeding were linked to a lowered chance of egg sensitisation when children were tested, that isn`t the same as food allergy.
Studies use egg-sensitisation tests to assess the risk of food allergy, but sensitisation does not necessarily mean an allergy will develop. We need to see longer-term studies that glance at the effects of supplements on real-world food allergies.
There were some further limitations.
Many of the studies looking at the effects of diet in pregnancy differed in the way they were carried out and reported.
Study results were inconclusive or inconsistent, meaning the researchers couldn`t be certain of any harms or benefits.
The 2013 cut-off for observational studies meant recent studies may own been missed.
The study didn`t glance at children`s diet beyond age 1, which might own an effect on allergies.
We will need to await any future updates to guidance or policy around diet or supplementation during pregnancy and breastfeeding, or feeding infants.
Discover out more about allergies and how to manage them.
If you`re pregnant, it`s significant to avoid any supplement, such as cod liver oil, that contains high levels of the retinol form of vitamin A. High doses of retinol can damage your baby.
If you live with a condition love osteoarthritis or depression, you may already know how it can affect other aspects of your health, contributing to issues love weight acquire, difficulty sleeping, and chronic pain.
One remedy said to ease depression, arthritis, and other conditions is the supplement SAMe, also known as ademetionine or S-adenosylmethionine.
SAMe is the synthetic form of a compound that is produced naturally in the body from methionine (an essential amino acid) and adenosine triphosphate (an energy-producing compound).
Commonly Known As
SAMe isn't found naturally in food. The body typically makes what it needs for excellent health, however, some disease states and low levels of methionine, folate, or vitamin B12 are believed to contribute to low levels of SAMe.
It's thought that SAMe can assist promote the production of chemicals known to frolic a key role in a variety of processes in the body, such as mood regulation, immune function, and pain perception.
SAMe is typically used for the following health issues:
SAMe is also said to enhance mental performance, boost liver health, slow the aging process, and assist people quit smoking.
What did the research involve?
Researchers searched for studies that looked at the effects of milk feeding (including breastfeeding) and diet of mothers and babies on children`s allergies.
They included observational studies from 1965 until July 2013 and interventional studies from 1965 until December 2017. The randomised controlled trials and observational studies were analysed separately.
They pooled figures from similar studies to calculate how interventions such as food supplements, or behaviour such as breastfeeding and general diet, affected the chances of children getting any type of allergy.
They checked the studies for potential bias and looked to see whether the pattern of results suggested that some studies with negative findings had not been published.
Here's a glance at some of the research on the possible benefits of SAMe.
In a research review published in the Journal of Complementary and Alternative Medicine in 2010, scientists looked at 70 previously published clinical trials evaluating the use of various types of complementary therapies for chronic fatigue syndrome and fibromyalgia.
Along with magnesium, L-carnitine, acupuncture, and several types of meditation practice, the review's authors named SAMe among the therapies with the most potential for further research on their effectiveness against these conditions.
SAMe shows promise in the treatment of osteoarthritis of the knee or hip. It is said to relieve pain and own anti-inflammatory properties, and some research suggests that it may promote cartilage repair.
In a report published in the Cochrane Database of Systematic Reviewsin 2009, researchers analyzed four previously published clinical trials (with a entire of 656 participants) and found that the use of SAMe may assist reduce pain and improve function in people with osteoarthritis.
Since the reviewed trials were of poor quality, however, the review's authors deemed these findings inconclusive.
SAMe was superior to a placebo when used with selective serotonin reuptake inhibitor (SSRI) antidepressants, but the evidence was considered low quality. Compared to imipramine, fewer participants experienced adverse effects when treated with an injectable form of SAMe. SAMe wasn't diverse from the placebo or antidepressants such as imipramine or escitalopram when used alone.
In their conclusion, the review's authors state that the use of SAMe for depression needs to be investigated further in larger and better-planned trials "given the absence of high-quality evidence and the inability to draw firm conclusions based on that evidence."
SAMe may improve liver function in people with chronic liver disease, suggests a research review published in the journal PLoS One in 2015.
However, in evaluating the 12 previously published clinical trials included in the review, the authors also found that SAMe may of limited benefit in the treatment of certain liver conditions such as viral hepatitis and cholestasis.
Where did the tale come from?
The study was carried out by researchers from Imperial College London, the University of Oxford and the University of Nottingham. It was funded by the UK Food Standards Agency and published in the peer-reviewed journal PLOS Medicine on an open-access basis, so it`s free to read online.
The study was covered widely in the UK media, with the focus mainly on the fish oil findings.
The reporting was generally precise, although the evidence would appear to be stronger for probiotics than fish oils.
How did the researchers interpret the results?
The researchers said they «found a relationship between maternal diet during pregnancy and lactation [breastfeeding] and eczema or allergic sensitisation to food during childhood» and that their findings «suggest that current infant-feeding guidance needs revision».