Atopic allergy what is
Protein family/group databases
|Allergomei||3371 Mala s 7.0101
473 Mala s 7
Family and domain databases
ProtoNet; Automatic hierarchical classification of proteins
MobiDB: a database of protein disorder and mobility annotations
<p>This section provides general information on the entry.<p><a href=’/help/entry_information_section’ target=’_top’>More…</a></p>Entry informationi
| <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier.
Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href=’/help/entry_name’ target=’_top’>More…</a></p>Entry namei
|<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href=’/help/accession_numbers’ target=’_top’>More…</a></p>Accessioni||O93971Primary (citable) accession number: O93971|
| <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the final sequence update and the date of the final annotation modification (‘Last modified’).
The version number for both the entry and the <a href=»http://www.uniprot.org/help/canonical_and_isoforms»>canonical sequence</a> are also displayed.<p><a href=’/help/entry_history’ target=’_top’>More…</a></p>Entry historyi
|Integrated into UniProtKB/TrEMBL:||May 1, 1999|
|Last sequence update:||May 1, 1999|
|Last modified:||December 11, 2019|
|This is version 29 of the entry and version 1 of the sequence.
See finish history.
|<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href=’/help/entry_status’ target=’_top’>More…</a></p>Entry statusi||Unreviewed (UniProtKB/TrEMBL)|
College: Washington & Lee University
Medical School: Medical University of South Carolina, Charleston
Internship and Residency: Medical College Of Virginia
Fellowship: University of North Carolina at Chapel Hill
Board Certified Pediatric Pulmonary
Ashe became interested in medicine in college, first as a volunteer then as an orderly. He saw how appreciative patients could be to the smallest quantity of care and attention.
Dr. Ashe was naturally drawn to pediatrics due to children’s honesty, directness, and ability to recover from the most serious conditions. He enjoys the uniqueness of pediatric pulmonary medicine and providing care to a variety of chronic illnesses such as premature lung diseases, Cystic Fibrosis, and asthma.
Dr. Ashe, also, is an advocate for children with debilitating handicaps. He greatly enjoys being a doctor and is rewarded everyday from his patients’ smiles of gratitude as they work together to enhance their quality of life.
Dr. Ashe specializes in pediatric respiratory and allergy diseases and has practiced in the Charlotte region for the past nineteen years. He is co-director of the Western Carolina Cystic Fibrosis Middle and Assistant Director of the Holy Angels Institute.
He has served on numerous pediatric medical committees and boards and is actively involved in medical education in the community. Dr. Ashe was awarded the Charlotte Top Docs Award in 2011, 2012, 2014 and 2015.
He enjoys a number of outdoor activities and is an avid golfer. He and his wife own 3 children.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritis and eczematous lesions with a worldwide prevalence of 15-20%.
The burden of disease is highest in the most developed nations and predominantly affects children, with 50% of cases arising in the first year of life, and most others arising in the first 5 years. There is a well-known increased susceptibility to skin infection with S. aureus in patients with AD, and such infections are associated with clinical deterioration. While it is routine to assess for S.
aureus colonization in the anterior nares, there is recent evidence suggesting that rectal colonization may be more significant. The significance of colonization site has not been evaluated in the AD population.
Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no routine data on the resistance to these agents.
Our purpose is to characterize the S. aureus colonization patterns in children with AD, including site of colonization and antibiotic resistance.
We will analyze routinely-collected skin culture specimens from children with AD seen at our middle and determine antibiotic susceptibility profiles. The significance of colonization site will be analyzed.
<p>This section displays by default the canonical protein sequence and upon request every isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href=»http://www.uniprot.org/help/sequence_length»>length</a> and <a href=»http://www.uniprot.org/help/sequences»>molecular weight</a>.
The information is filed in diverse subsections. The current subsections and their content are listed below:<p><a href=’/help/sequences_section’ target=’_top’>More…</a></p>Sequencei
<p>This subsection of the <a href=»http://www.uniprot.org/help/sequences_section»>Sequence</a> section indicates if the <a href=»http://www.uniprot.org/help/canonical_and_isoforms»>canonical sequence</a> displayed by default in the entry is finish or not.<p><a href=’/help/sequence_status’ target=’_top’>More…</a></p>Sequence statusi: Fragment.
|Feature key||Position(s)||DescriptionActions||Graphical view||Length|
|<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the finish protein sequence.<p><a href=’/help/non_ter’ target=’_top’>More…</a></p>Non-terminal residuei||1||
Automatic assertion inferred from database entriesi
O93971-1 [UniParc]FASTAAdd to basketAdded to basket« Hide 10 20 30 40 50
AVSASPTPSK HNLYCYAQGK DLFEFHINDT VTKDVCKSLN SGKYHNMNNE
60 70 80 90 100
KYCSVADYDV KWFKERCQSH PTDVKTTKWI AGTDLKIEMD PKEPYELYCF
110 120 130 140 150
NYYTTFGNLP DAGAKELDDD ATKKACSALK SGKYQSDPKK KSCRMDKKDI
160 170 180
DQFKEQCSQY QPSDRPPYGD WSAGTSLNVV LNLKKNA
May 1, 1999 — v1
<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at diverse levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href=»http://www.uniprot.org/help/uniref»>UniRef</a>).<p><a href=’/help/similar_proteins_section’ target=’_top’>More…</a></p>Similar proteinsi
Caring for one patient at a time
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